A polymorphism in HLA-G modifies statin benefit in asthma
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چکیده
منابع مشابه
Human platelet antigen polymorphism in bronchial asthma
Background: Asthma is recognized as a common cause of disability, of great economic cost, and of preventable deaths. In this study we aimed to test our hypothesis to evaluate the relationship between the Human Platelet Antigen-1(HPA-1) polymorphism and bronchial asthma and its severity, which would suggest genetic variances that may be responsible for expression or activation of these receptors...
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Humans are the most adaptable species among living organisms. Adaptation is the sum of all processes which allows the organism to cope with environmental stresses, in particular climate and topography, for its survival. All living species continuing through time and space to the present day are endowed with innate biological adaptation. The whole gamut of biological adaptation of human species ...
متن کاملHuman Leukocyte Antigen-G (HLA-G) Polymorphism and Expression in Breast Cancer Patients
Human leukocyte antigen-G (HLA-G) is known to be implicated in a tumor-driven immune escape mechanism in malignancies. The purpose of this study was to investigate HLA-G polymorphism and expression in breast cancer. HLA-G alleles were determined by direct DNA sequencing procedures from blood samples of 80 breast cancer patients and 80 healthy controls. Soluble HLA-G (sHLA-G) was measured by enz...
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Background—Despite the known benefit of intensive statin therapy for reducing future cardiovascular events, its effectiveness in women has been questioned by some. Methods and Results—In the Pravastatin or Atorvastatin Evaluation and Infection Therapy—Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) trial, 911 (21.9%) women and 3251 (78.1%) men were randomized to intensive statin (at...
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ژورنال
عنوان ژورنال: The Pharmacogenomics Journal
سال: 2014
ISSN: 1470-269X,1473-1150
DOI: 10.1038/tpj.2014.55